No. 5 Florida State 51, No. 4 Clemson 14: Redshirt freshman phenom Jameis Winston passed for 444 yards and three touchdowns and added a rushing score as the visiting Seminoles turned the highly-anticipated ACC showdown into a blowout.

Winston was 22-of-34 and went over 300 yards for the fourth time in six career games, and Rashad Greene caught eight passes for 146 yards and two touchdowns for Florida State (6-0, 4-0 ACC), which won at Clemson for the first time since 2001. Nick O'Leary added five catches for 161 yards.

The Seminoles shut down Tajh Boyd and the Tigers, holding Clemson (6-1, 4-1) to 326 total yards and forcing four turnovers. Boyd finished 17-of-37 for 156 yards with two interceptions and a fumble that Florida State's Mario Edwards Jr. returned for a touchdown.

Florida State set the tone early as Lamarcus Joyner stripped Stanton Seckinger on the first play from scrimmage, setting up Winston's 22-yard scoring pass to Kelvin Benjamin three plays later. Joyner struck again with a sack and forced fumble that Edwards scooped up for a 37-yard touchdown, and he added an interception to set up Roberto Aguayo's second field goal for a 27-7 halftime lead.

The rout continued in the second half as the Seminoles scored touchdowns on three of their first four possessions. Winston and Greene hooked up for their second touchdown coming out of the break, and Winston and Devonta Freeman added touchdown runs.

GAME NOTEBOOK: The loss was the most lopsided at home for Clemson since a 41-0 defeat against Georgia in 1976. … Boyd's 79.5 passer efficiency rating was his lowest since a 66.5 mark in a loss to South Carolina in 2011. … Florida State RB James Wilder Jr. was knocked out of the game with a concussion on the Seminoles' second possession.